NephroPlex™ (肾来平™) Human Serum/Plasma Poly-IgA Complex Detection Kit (ELISA)
Product Description:
NephroPlex™, developed by Lujing Biotechnology, is based on the exclusive patented molecular probe technology to detect poly-IgA immune complexes in peripheral blood (mainly the cause of renal pathological deposition). It is verified that this index can be used as a valid index for the assessment of immune activity in IgA nephropathy.
The poly-IgA immune complex as a specific molecular marker of IgA nephropathy in serum (initiated by Lujing Biotechnoly) will lead |gA chronic kidney disease immune activity assessment, early warning, auxiliary diagnosis, and a major breakthrough in the management of the complete life cycle of patients.
Comparison of survival rate of high/low IgA immune activity index populations (K-M curve)
Detection strengths:
The method is simple; stability, repeatability and accuracy are good.
Clinical Application Value:
- a. Specific identification of pathogenic poly-IgA complexes; better diagnosis than traditional biomarkers.
- b. The treatment prediction and efficacy evaluation of IgA nephropathy can prompt the response of hormone therapy.
Immune Activity Index（Poly-IgA Index）Outperformed Overall IgA1 and Gd-IgA1
Effective treatment significantly reduces IgA complex markers
References
- 1. [ZHANG2021]Zhang X，et.al.Poly-IgA Complexes and Disease Severity in IgA Nephropathy.CJASN 16：1652 1664，2021.doi:https://doi.org/10.2215/CJN.01300121
- 2. [LV2019]LvJC，et.al.一种用于血清学诊断IgA肾病的分子探针。专利申请号：201910857929.9
- 3. Human Fc Fragment Of IgA Receptor / CD89 (FCAR) ELISA Kit
- 4. IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
- 5. FcαRI/CD89 Circulates in Human Serum Covalently Linked to IgA in a Polymeric State
- 6. Interactions of human mesangial cells with IgA and IgA-containing immune complexes
- 7. Complexes of IgA with FcaRI/CD89 are not specific for primary IgA nephropathy
- 8. Deglycosylation of FcαR at N58 increases its binding to IgA